This museum was opened in 1975 in Tepebasi by the Istanbul Municipality through the efforts of the Caricaturists Association, then temporarily closed down in 1980 as the building where it was housed was torn down and later re-opened in its new site in Fatih district.

The Gazanfer Aga complex, which consists of an Ottoman medrese, a shrine and a fountain in Sarachanebasi, was restored for use as the new structure. Re-opened in 1989, the museum contains a rich collection of satirical works, written or drawn, and the exhibits are frequently changed.

Caricature and Humor Arts Museum was originally opened for service in 1975 by the initiatives of Caricature Artists Association in Tepebasi. Caricature and Humor Arts Museum which was closed in 1980 was reopened to service in 1989 again with the efforts of the in Gazanfer Aga.

The collection of the museum features various documents and authentic works, selections from caricature and humor periodicals from Turkey and the world.